Publications

Selected Publications


2025

LUBAC modulates CBM complex functions downstream of TRAF6 in T cells. Graß C, Ober F, Sixt C, Moud BN, Antoshkina I, Eberstadt F, Puhach A, Avar G, Keßler A, O’Neill TJ, Seeholzer T, Kranich J, Brocker T, Lammens K, Menden MP, Zielinski CE, Krappmann D. Nat Commun. 2025 Nov 10;16(1):9899. doi: 10.1038/s41467-025-65879-6.PMID: 41213928

Sex differences in sepsis outcomes across the lifespan: a population-based cohort study in Germany. Rose N, Agrama I, Nachtigall I, Pletz MW, Rosendahl J, Chung HY, Zielinski CE, Dudziak D, Spoden M, Dröge P, Hagel S, Fleischmann-Struzek C. Crit Care. 2025 Sep 26;29(1):408. doi: 10.1186/s13054-025-05657-4.PMID: 41013702

 Ingestion of mast cell granules boosts macrophages and drives atypical programming. Konstantinos Katsoulis-Dimitriou, Julia Schmidt, Marc Roder, Jan Dudeck, Lars Philipsen, James P Koch, Maria Cattelan, Lea Schmitter, Olga Biskou, Aaron Hoffmann, Michael Mihlan, Rohit Sharma 1, Johanna Kotrba 1, Martin Voss, Mahsa Abedi, Ina Sauerland, Stefan Frischbutter, Christina E Zielinski, Robert Geffers, Tim Lämmermann, Andreas J Müller, Sascha Kahlfuß, Anne Dudeck .J Allergy Clin Immunol 2025 May 26:S0091-6749(25)00576-7.doi: 10.1016/j.jaci.2025.04.035.

2024

Dominik Soll#, Chang-Feng Chu#, Shan Sun#, Veronika Lutz, Mahima Arunkumar, Mariam Gachechiladze, Sascha Schäuble, Maha Alissa-Alkhalaf, Trang Nguyen, Michelle-Amirah Khalil, Ignacio Garcia-Ribelles, Michael Mueller, Katrin Buder, Bernhard Michalke, Gianni Panagiotou4,11, Kai Ziegler-Martin, Pascal Benz, Philipp Schatzlmaier, Karsten Hiller, Hannes Stockinger, Maik Luu, Kilian Schober, Carolin Moosmann, Wolfgang W. Schamel, Magdalena Huber, Christina E. Zielinski. Sodium chloride in the tumor microenvironment enhances T-cell metabolic fitness and cytotoxicity. Nat Immunol (2024). https://doi.org/10.1038/s41590-024-01918-6 https://www.nature.com/articles/s41590-024-01918-6

Deng Y, Yu R, Grabe V, Sommermann T, Werner M, Vallet M, Zerfaß C, Werz O, Pohnert G. Bacteria modulate microalgal aging physiology through the induction of extracellular vesicle production to remove harmful metabolites. Nat Microbiol. 2024 Sep;9(9):2356-2368. doi: 10.1038/s41564-024-01746-2. Epub 2024 Aug 14.PMID: 39143356 

The impact of high salt diet on asthma in humans and mice: effect on specific T-cell signatures and microbiome. Stephanie Musiol, Carla P. Harris, Silvia Gschwendtner, Amy Burrell, Yacine Amar, Benjamin Schnautz, Dennis Renisch, Sonja C. Braun, Stefan Haak, Michael Schloter, Carsten B. Schmidt-Weber, Christina E. Zielinski, Francesca Alessandrini. Allergy 2024. DOI: 10.1111/all.16148

Single-Cell RNA Sequencing Reveals HIF1A as a Severity-Sensitive Immunological Scar in Circulating Monocytes of Convalescent Comorbidity-Free COVID-19 Patients. Lilly May, Chang-Feng Chu, Christina E. Zielinski. Cells 2024, 13(4), 300; https://doi.org/10.3390/cells13040300 – 06 Feb 2024

2023

Sodium chloride in the tumor microenvironment enhances T-cell metabolic fitness and cytotoxicity Dominik Soll, Mahima Arunkumar, Maha Alissa-Alkhalaf, Shan Sun, Trang Nguyen, Chang-Feng Chu, Veronika Lutz, Sascha Schauble, Ignacio Garcia-Ribelles, Michael Mueller, Bernhard Michalke, GianniPanagiotou, Philipp Schatzlmaier, Hannes Stockinger, Wolfram Schamel, Magdalena Huber, Christina E Zielinski. bioRxiv 2023.09.14.557686; doi: https://doi.org/10.1101/2023.09.14.557686

A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity. Philippa Meiser, Moritz A. Knolle, Anna Hirschberger, Gustavo P. de Almeida, Felix Bayerl, Sebastian Lacher, Anna-Marie Pedde, Sophie Flommersfeld, Julian Hönninger, Leonhard Stark, Fabian Stögbauer, Martina Anton, Markus Wirth, Dirk Wohlleber, Katja Steiger, Veit R. Buchholz, Barbara Wollenberg, Christina E. Zielinski, Rickmer Braren, Daniel Rückert, Percy A. Knolle, Georgios Kaissis, Jan P. Böttcher. 2023. Cancer Cell. https://doi.org/10.1016/j.ccell.2023.06.008

T helper cell subsets: diversification of the field. Zielinski CE. Eur J Immunol. 2023 Feb 15:e2250218. doi: 10.1002/eji.202250218. Online ahead of print.PMID: 36792132 Review.

Human Th17 cells engage gasdermin E pores to release IL-1α upon NLRP3 inflammasome activation. Chao YY, Puhach A, Frieser D, Arunkumar M, Lehner L, Seeholzer T, Garcia-Lopez A, van der Wal M, Fibi-Smetana S, Dietschmann A, Sommermann T, Taher L, Gresnigt MS, Vastert SJ, van Wijk F, Panagiotou G, Krappmann D, Groß O, Zielinski CE (2023). Nature Immunology, doi: 10.1038/s41590-022-01386-w

News and Views Nature Immunology: https://rdcu.be/c3RD2

2022

A scoping review of regulatory T cell dynamics in convalescent COVID-19 patients – indications for their potential involvement in the development of Long COVID Haunhorst S, Bloch W, Javelle F, Krüger K, Baumgart S, Drube S, Lemhöfer C, Reuken P, Stallmach A, Müller M, Zielinski CE, Pletz MW, Gabriel HHW, Puta C. Front Immunol. 2022 Dec 13;13:1070994. doi: 10.3389/fimmu.2022.1070994. eCollection 2022.PMID: 36582234 

Meeting Report: 47th Annual Meeting of the “Arbeitsgemeinschaft Dermatologische Forschung”. Georg Stary, Mario Fabri, Christoffer Gebhardt, Rüdiger Eming, Julia Matthias, Artem Vorobyev, Maike Effern, Johanna Strobl, Claudia Günther, Christina Zielinski, Diana Dudziak, Cyril Géraud, Verena Raker, Monique Butze, Fang Zhao, Yuanyuan Wang, Dennis Gerloff, Nicole L. Bertschi, Evelyn Gaffal, Timo Buhl. Experimental Dermatology. March 2022.

Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential. de Almeida GP, Lichtner P, Eckstein G, Brinkschmidt T, Chu CF, Sun S, Reinhard J, Mädler SC, Kloeppel M, Verbeek M, Zielinski CE. Sci Immunol. 2022 Jan 28;7(67):eabe2634. doi: 10.1126/sciimmunol.abe2634. Epub 2022 Jan 28.PMID: 35089814 https://www.science.org/stoken/author-tokens/ST-307/full

A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells.Yin H, Karayel O, Chao YY, Seeholzer T, Hamp I, Plettenburg O, Gehring T, Zielinski C, Mann M, Krappmann D. Cell Mol Life Sci. 2022 Jan 31;79(2):112. doi: 10.1007/s00018-022-04154-z.PMID: 35099607

2021


T-Cell Receptor Repertoire Analysis with Computational Tools-An Immunologist’s Perspective. Arunkumar M, Zielinski CE. Cells. 2021 Dec 18;10(12):3582. doi: 10.3390/cells10123582.PMID: 34944090 Free PMC article. Review.

Regulation of T Cell Responses by Ionic Salt Signals. Zielinski CE. Cells. 2021 Sep 9;10(9):2365. doi: 10.3390/cells10092365.PMID: 34572015 

Characterization of a library of 20 HBV-specific MHC class II-restricted T cell receptors.Schreiber S, Honz M, Mamozai W, Kurktschiev P, Schiemann M, Witter K, Moore E, Zielinski C, Sette A, Protzer U, Wisskirchen K. Mol Ther Methods Clin Dev. 2021 Oct 29;23:476-489. doi: 10.1016/j.omtm.2021.10.012. eCollection 2021 Dec 10.

Convalescent COVID-19 Patients Without Comorbidities Display Similar Immunophenotypes Over Time Despite Divergent Disease Severities. Chu, C.F., Sabath, F., Fibi-Smetana S., Sun, S., Öllinger, R., Noessner, E., Chao, Y.Y., Rinke, L., Winheim, E., Rad, R., Krug, A.B., Taher, L., Zielinski, C.E. Front. Immunol., 19 August 2021 https://doi.org/10.3389/fimmu.2021.601080

2020

  • Matthias J, Heink S, Picard FS, Zeiträg J, Kolz A, Chao YY, Soll D, de Almeida GP, Glasmacher E, Jacobsen ID, Riedel T, Peters A, Floess S, Huehn J, Baumjohann D, Huber M, Korn T, Zielinski CE: “Salt generates anti-inflammatory Th17 cells but amplifies their pathogenicity in pro-inflammatory cytokine microenvironments”. J Clin Invest. 2020; 10.1172/JCI137786.

 

  • Chang-Feng Chu, Florian Sabath, Shan Sun, Ying-Yin Chao, Christina E. Zielinski. In depth phenotying of peripheral blood mononuclear cells in convalescent COVID-19 patients following a mild versus severe disease course. https://www.medrxiv.org/content/10.1101/2020.05.25.20112763v1

 

 

  • Christina Zielinski, Julia Mattias. Allergische Erkrankungen bei Erwachsenen – Prävalenz, Bedeutung und Implikationen für die Prävention und Gesundheitförderung. Book (Springer-Verlag). https://doi.org/10.1007/978-3-662-55793-8_65-1

 

 

 

 

 

 

  • Zielinski CE. Human T cell immune surveillance: Phenotypic, functional and migratory heterogeneity for tailored immune responses. Immunol Lett. 2017 Oct;190:125-129. doi: 10.1016/j.imlet.2017.08.001. Epub 2017 Aug 4. Review. PubMed PMID: 28827022 [Pubmed]

 

  • Pascual-Reguant A, Bayat Sarmadi J, Baumann C, Noster R, Cirera-Salinas D, Curato C, Pelczar P, Huber S, Zielinski CE, Löhning M, Hauser AE, Esplugues E. TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine. Mucosal Immunol. 2017 Feb 15. doi: 10.1038/mi.2017.5 [Pubmed]

 

  • Tagawa T, Albanese M, Bouvet M, Moosmann A, Mautner J, Heissmeyer V, Zielinski C, Lutter D, Hoser J, Hastreiter M, et al. Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing. J Exp Med. 2016;213(10):2065-80 [Pubmed]

 

  • Barmeyer C, Schumann M, Meyer T, Zielinski C, Zuberbier T, Siegmund B, Schulzke JD, Daum S, and Ullrich R. Long-term response to gluten-free diet as evidence for non-celiac wheat sensitivity in one third of patients with diarrhea-dominant and mixed-type irritable bowel syndrome. Int J Colorectal Dis. 2016 [Pubmed]

 

  • Poltorak MP, and Zielinski CE. Hierarchical governance of cytokine production by 6-sulfo LacNAc (slan) dendritic cells for the control of psoriasis pathogenesis. Exp Dermatol. 2016 [Pubmed]

 

  • Noster R, de Koning HD, Maier E, Prelog M, Lainka E, Zielinski CE. Dysregulation of proinflammatory versus anti-inflammatory human Th17 cell functionalities in the autoinflammatory Schnitzler syndrome. J Allergy Clin Immunol. 2016 Mar 31. pii: S0091-6749(16)00266-9. doi: 10.1016/j.jaci.2015.12.1338 [Pubmed]

 

  • Noster R, Riedel R, Mashreghi MF, Radbruch H, Harms L, Haftmann C, Chang HD, Radbruch A, Zielinski CE. IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells. Sci Transl Med. 2014 Jun 18;6(241):241ra80 [Pubmed]

 

  • Zielinski CE. Autoimmunity beyond Th17: GM-CSF producing T cells. Cell Cycle. 2014;13(16):2489-90 [Pubmed]

 

  • Eyerich S, Zielinski CE. Defining Th-cell subsets in a classical and tissue-specific manner: Examples from the skin. Eur J Immunol. 2014 Dec;44(12):3475-83 [Pubmed]

 

  • Zielinski CE. Microbe driven T helper cell differentiation – lessons from C.albicans and S.aureus. Exp Dermatol. 2014 Nov;23(11):795-8 [Pubmed]

 

  • Braun JM, Zielinski CE. In vitro generation of microbe-specific human Th17 cells. Methods Mol Biol. 2014;1193:97-104 [Pubmed]

 

  • Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, and Sallusto F. Pathogen-induced Th17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta Nature. 2012 Apr; 484:514-8 [Pubmed]

 

  • Zielinski CE, Zuberbier T, Maurer M. Immunoregulation in cutaneous allergy–prevention and control. Curr Opin Allergy Clin Immunol. 2012 Oct;12(5):498-503 [Pubmed]

 

  • Nicole Rusca, Lorenzo Deho, Sara Montagner, Christina E. Zielinski, Antonio Sica, Federica Sallusto, Silvia Monticelli. MiR-146a and NF-kappaB1 regulate mast cell survival and T lymphocyte differentiation. Mol. Cell. Biol. 2012, Nov;32(21):4432-44. [Pubmed]

 

  • Sallusto F, Zielinski CE, Lanzaveccia A. Human Th17 subsets. Eur J Immunol. 2012, Sep;42(9):2215-20 [Pubmed]

 

  • Zielinski CE, Corti D, Mele F, Pinto D, Lanzavecchia A, Sallusto F. Dissecting the human immunological memory against pathogens. Immunol Rev. 2011 Mar;240(1):40-51 [Pubmed]

 

  • Zielinski CE, Jacob SN, Bouzahzah F, Ehrlich BE, Craft J. Naïve CD4+ T cells from lupus-prone Fas-intact MRL mice display TCR-mediated hyperproliferation due to intrinsic threshold defects in activation. J Immunol. 2005 Apr 15;174(8):5100-9 [Pubmed]