Selected Publications

2023

T helper cell subsets: diversification of the field. Zielinski CE.Eur J Immunol. 2023 Feb 15:e2250218. doi: 10.1002/eji.202250218. Online ahead of print.PMID: 36792132 Review.

Human Th17 cells engage gasdermin E pores to release IL-1α upon NLRP3 inflammasome activation. Chao YY, Puhach A_,Frieser D,Arunkumar M,Lehner L,Seeholzer T, Garcia-Lopez A, van der Wal M,Fibi-Smetana S,Dietschmann A, Sommermann T, Taher L, Gresnigt MS, Vastert SJ, van Wijk F, Panagiotou G_,Krappmann D, Groß O, Zielinski CE (2023). Nature Immunology, doi: 10.1038/s41590-022-01386-w

News and Views Nature Immunology: https://rdcu.be/c3RD2

2022

A scoping review of regulatory T cell dynamics in convalescent COVID-19 patients – indications for their potential involvement in the development of Long COVID Haunhorst S, Bloch W, Javelle F, Krüger K, Baumgart S, Drube S, Lemhöfer C, Reuken P, Stallmach A, Müller M, Zielinski CE, Pletz MW, Gabriel HHW, Puta C. Front Immunol. 2022 Dec 13;13:1070994. doi: 10.3389/fimmu.2022.1070994. eCollection 2022.PMID: 36582234

Meeting Report: 47th Annual Meeting of the “Arbeitsgemeinschaft Dermatologische Forschung”. Georg Stary, Mario Fabri, Christoffer Gebhardt, Rüdiger Eming, Julia Matthias, Artem Vorobyev, Maike Effern, Johanna Strobl, Claudia Günther, Christina Zielinski, Diana Dudziak, Cyril Géraud, Verena Raker, Monique Butze, Fang Zhao, Yuanyuan Wang, Dennis Gerloff, Nicole L. Bertschi, Evelyn Gaffal, Timo Buhl. Experimental Dermatology. March 2022.

Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential. de Almeida GP, Lichtner P, Eckstein G, Brinkschmidt T, Chu CF, Sun S, Reinhard J, Mädler SC, Kloeppel M, Verbeek M, Zielinski CE. Sci Immunol. 2022 Jan 28;7(67):eabe2634. doi: 10.1126/sciimmunol.abe2634. Epub 2022 Jan 28.PMID: 35089814 https://www.science.org/stoken/author-tokens/ST-307/full

A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells.Yin H, Karayel O, Chao YY, Seeholzer T, Hamp I, Plettenburg O, Gehring T, Zielinski C, Mann M, Krappmann D. Cell Mol Life Sci. 2022 Jan 31;79(2):112. doi: 10.1007/s00018-022-04154-z.PMID: 35099607

2021

T-Cell Receptor Repertoire Analysis with Computational Tools-An Immunologist’s Perspective. Arunkumar M, Zielinski CE. Cells. 2021 Dec 18;10(12):3582. doi: 10.3390/cells10123582.PMID: 34944090 Free PMC article. Review.

Regulation of T Cell Responses by Ionic Salt Signals. Zielinski CE. Cells. 2021 Sep 9;10(9):2365. doi: 10.3390/cells10092365.PMID: 34572015

Characterization of a library of 20 HBV-specific MHC class II-restricted T cell receptors.Schreiber S, Honz M, Mamozai W, Kurktschiev P, Schiemann M, Witter K, Moore E, Zielinski C, Sette A, Protzer U, Wisskirchen K. Mol Ther Methods Clin Dev. 2021 Oct 29;23:476-489. doi: 10.1016/j.omtm.2021.10.012. eCollection 2021 Dec 10.

Convalescent COVID-19 Patients Without Comorbidities Display Similar Immunophenotypes Over Time Despite Divergent Disease Severities. Chu, C.F., Sabath, F., Fibi-Smetana S., Sun, S., Öllinger, R., Noessner, E., Chao, Y.Y., Rinke, L., Winheim, E., Rad, R., Krug, A.B., Taher, L., Zielinski, C.E. Front. Immunol., 19 August 2021 https://doi.org/10.3389/fimmu.2021.601080

2020

Matthias J, Heink S, Picard FS, Zeiträg J, Kolz A, Chao YY, Soll D, de Almeida GP, Glasmacher E, Jacobsen ID, Riedel T, Peters A, Floess S, Huehn J, Baumjohann D, Huber M, Korn T, Zielinski CE: “Salt generates anti-inflammatory Th17 cells but amplifies their pathogenicity in pro-inflammatory cytokine microenvironments”. J Clin Invest. 2020; 10.1172/JCI137786.

Chang-Feng Chu, Florian Sabath, Shan Sun, Ying-Yin Chao, Christina E. Zielinski. In depth phenotying of peripheral blood mononuclear cells in convalescent COVID-19 patients following a mild versus severe disease course. https://www.medrxiv.org/content/10.1101/2020.05.25.20112763v1

Gustavo P. de Almeida, Peter Lichtner, Sophia Mädler, Chang-Feng Chu, Christina E. Zielinski. Transcriptional profiling and single-cell chimerism analysis identifies human tissue resident T cells in the human skin after allogeneic stem cell transplantation. bioRxiv 2020.04.11.037101; doi: https://doi.org/10.1101/2020.04.11.037101

Christina Zielinski, Julia Mattias. Allergische Erkrankungen bei Erwachsenen – Prävalenz, Bedeutung und Implikationen für die Prävention und Gesundheitförderung. Book (Springer-Verlag). https://doi.org/10.1007/978-3-662-55793-8_65-1

Cossarizza A et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol. 2019 Oct;49(10):1457-1973. doi: 10.1002/eji.201970107.

Matthias J, Zielinski CE. Shaping the diversity of Th2 cell responses in epithelial tissues and its potential for allergy treatment. Eur J Immunol. 2019. July 5. Review. doi: 10.1002/eji.201848011

Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M. IL-17⁺ CD8⁺ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis. Nat Commun. 2019 Dec 16;10(1):5722. doi: 10.1038/s41467-019-13731-z.

Palit S, Heuser C, de Almeida GP, Theis FJ, Zielinski CE. Meeting the Challenges of High-Dimensional Single-Cell Data Analysis in Immunology. Front Immunol. 2019, July 3. Review. doi: 10.3389/fimmu.2019.01515

Matthias J, Maul J, Noster R, Meinl H, Chao Y, Gerstenberg H, Jeschke F, Gasparoni G, Welle A, Walter J, Nordström K, Eberhardt K, Renisch D, Donakonda S, Knolle P, Soll D, Grabbe S, Garzorz-Stark N, Eyerich K, Biedermann T, Baumjohann D, Zielinski CE. Sodium chloride is an ionic checkpoint for human T_H2 cells and shapes the atopic skin microenvironment. Sci Transl Med. 2019, Feb 20. doi: 10.1126/scitranslmed.aau0683

Zielinski CE. Human T cell immune surveillance: Phenotypic, functional and migratory heterogeneity for tailored immune responses. Immunol Lett. 2017 Oct;190:125-129. doi: 10.1016/j.imlet.2017.08.001. Epub 2017 Aug 4. Review. PubMed PMID: 28827022 [Pubmed]

Pascual-Reguant A, Bayat Sarmadi J, Baumann C, Noster R, Cirera-Salinas D, Curato C, Pelczar P, Huber S, Zielinski CE, Löhning M, Hauser AE, Esplugues E. TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine. Mucosal Immunol. 2017 Feb 15. doi: 10.1038/mi.2017.5 [Pubmed]

Tagawa T, Albanese M, Bouvet M, Moosmann A, Mautner J, Heissmeyer V, Zielinski C, Lutter D, Hoser J, Hastreiter M, et al. Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing. J Exp Med. 2016;213(10):2065-80 [Pubmed]

Barmeyer C, Schumann M, Meyer T, Zielinski C, Zuberbier T, Siegmund B, Schulzke JD, Daum S, and Ullrich R. Long-term response to gluten-free diet as evidence for non-celiac wheat sensitivity in one third of patients with diarrhea-dominant and mixed-type irritable bowel syndrome. Int J Colorectal Dis. 2016 [Pubmed]

Poltorak MP, and Zielinski CE. Hierarchical governance of cytokine production by 6-sulfo LacNAc (slan) dendritic cells for the control of psoriasis pathogenesis. Exp Dermatol. 2016 [Pubmed]

Noster R, de Koning HD, Maier E, Prelog M, Lainka E, Zielinski CE. Dysregulation of proinflammatory versus anti-inflammatory human Th17 cell functionalities in the autoinflammatory Schnitzler syndrome. J Allergy Clin Immunol. 2016 Mar 31. pii: S0091-6749(16)00266-9. doi: 10.1016/j.jaci.2015.12.1338 [Pubmed]

Noster R, Riedel R, Mashreghi MF, Radbruch H, Harms L, Haftmann C, Chang HD, Radbruch A, Zielinski CE. IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells. Sci Transl Med. 2014 Jun 18;6(241):241ra80 [Pubmed]

Zielinski CE. Autoimmunity beyond Th17: GM-CSF producing T cells. Cell Cycle. 2014;13(16):2489-90 [Pubmed]

Eyerich S, Zielinski CE. Defining Th-cell subsets in a classical and tissue-specific manner: Examples from the skin. Eur J Immunol. 2014 Dec;44(12):3475-83 [Pubmed]

Zielinski CE. Microbe driven T helper cell differentiation – lessons from C.albicans and S.aureus. Exp Dermatol. 2014 Nov;23(11):795-8 [Pubmed]

Braun JM, Zielinski CE. In vitro generation of microbe-specific human Th17 cells. Methods Mol Biol. 2014;1193:97-104 [Pubmed]

Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, and Sallusto F. Pathogen-induced Th17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta Nature. 2012 Apr; 484:514-8 [Pubmed]

Zielinski CE, Zuberbier T, Maurer M. Immunoregulation in cutaneous allergy–prevention and control. Curr Opin Allergy Clin Immunol. 2012 Oct;12(5):498-503 [Pubmed]

Nicole Rusca, Lorenzo Deho, Sara Montagner, Christina E. Zielinski, Antonio Sica, Federica Sallusto, Silvia Monticelli. MiR-146a and NF-kappaB1 regulate mast cell survival and T lymphocyte differentiation. Mol. Cell. Biol. 2012, Nov;32(21):4432-44. [Pubmed]

Sallusto F, Zielinski CE, Lanzaveccia A. Human Th17 subsets. Eur J Immunol. 2012, Sep;42(9):2215-20 [Pubmed]

Zielinski CE, Corti D, Mele F, Pinto D, Lanzavecchia A, Sallusto F. Dissecting the human immunological memory against pathogens. Immunol Rev. 2011 Mar;240(1):40-51 [Pubmed]

Zielinski CE, Jacob SN, Bouzahzah F, Ehrlich BE, Craft J. Naïve CD4+ T cells from lupus-prone Fas-intact MRL mice display TCR-mediated hyperproliferation due to intrinsic threshold defects in activation. J Immunol. 2005 Apr 15;174(8):5100-9 [Pubmed]